Curcumin has anti-inflammatory, anti-oxidative, anti-fibrosis, anti-induced apoptosis of the eye pharmacological effects, but because of curcumin water-soluble low, how to increase its eye bioavailability is ophthalmic preparations need to solve the problem.
Cyclodextrin can increase the solubility and stability of lipophilic drugs by solubilization in ophthalmic prescriptions to avoid increasing the solubility of lipophilic drugs in water by using organic solvents, enhancing the bioavailability and stability of the drug in the eye Sex. In recent years, more and more research on its derivatives, hydroxypropyl-β-cyclodextrin (hydroxypropyl-β-CD, HP-β-CD) in the water solubility is higher, so relative to the β-CD, HP -β-CD is more useful in ophthalmic preparations. It is a new type of ocular absorption enhancer with strong tolerance, safety and low irritation by penetrating into the cell membrane through ocular tissue. The sulfobutyl ether-β-CD-SB-β-CD was negatively charged compared to neutral HP-β-CD, with 7 sodium Ions, can be completely dissociated in the water, the formation of a strong osmotic pressure, can significantly improve the stability of the drug, and significantly reduce the irritation of the drug on the eye. Compared with the two kinds of cyclodextrins, SBE-β-CD as an excipient of eye drops not only significantly reduces the irritation of the eye to the eye, but also significantly increases the drug stability and is excellent in ophthalmic preparations Potential, is expected to become efficient and safe penetration enhancer.
Sulfobutyl/Methyl Beta Cyclodextrin including Sulfobutyl Beta Cyclodextrin and Methyl Beta Cyclodextrin.
Our offered Sulfobutyl Ether Beta Cyclodextrin Sodium is sulfonated modified sodium salt of Betacyclodextrin. It`s also called butyl ether Betacyclodextrin thiosulfate sodium. The appearance is light yellow or white powder, it`s our new developed new type pharmaceutical preparations excipient products and be the best water-soluble cyclodextrin products for the current series of cyclodextrin. It`s mainly used as an insoluble drug carrier, which can significantly improve drug solubility and bioavailability. The product quality is excellent and has been quantities exported to India, the United States and other markets.
Packing and storage:
The packing meets the national pharmaceutical packaging requirements
Specifications: 15 kg / drum
Storage and transportation: It should be protected against moisture, water, fire and pollution.
Clients can avail this Sulfobutyl Ether Beta Cyclodextrin Sodium at industry leading prices from us.
Methyl beta cyclodextrin(Beta-cyclodextrin, methyl ethers)is one kind of modified beta-cyclodextrin, it has not only the general chanracteristics of Betacyclodextrin, but also has better solubility, especially for oiles. In medicine Methyl-beta-cyclodextrin can increase the solubility of the medicine, increase the good effect and reduce the number. At the same time, it can control the reactive speed of the medicine, increase the stability of it. Methyl-beta-cyclodextrin is mainly used in oral medicine.
Package: Chinese qualified wrappage.
Style:
Advanced and strong container: 10kg/carton
Paper and wooden container: 10kg/fiber drum
Caution Away from water, wet, fire and pollution
Sulfobutyl/Methyl Beta Cyclodextrin
Methyl Beta Cyclodextrin, Sulfobutyl Beta Cyclodextrin,Methyl Beta Cyclodextrin,Brown Methyl Beta Cyclodextrin
Zhiyuan Biotchnology , http://www.zycydextrin.com